If you really want to get away from it all in Missouri, you have a lot of options. However, there is one place in the state that is further away from civilization than any other, but you can hike to it.
The best of anything is a very subjective opinion. However, in this case I believe that you can at least say this Missouri play area is one of the best in the state and the best part is it's an easy day trip to just west of Wentzville.
I'm exhausted following their journey and I'm not even the one hiking. A couple who are currently on an adventure to hike across America are currently right in the middle of Missouri.